Relationship between plasma leptin and plasma insulin levels in type-2 diabetic patients before and after treatment with glibenclamide and glimepiride.
نویسندگان
چکیده
Type 2 diabetes affects 100 million people throughout the world. Among the various factors implicated in the causation of this disease, the role of leptin, an obesity gene product, is increasingly being investigated. This especially assumes importance in the light of knowledge that obesity confers a minimum of 3-10 fold higher risk of diabetes. This study was planned to investigate the relationship between leptin and insulin levels in type 2 diabetic patients before and after treatment with glibenclamide or glimepiride. 60 type 2 diabetic patients were recruited for the study and were divided into 2 groups-one receiving glimepiride and the other group receiving glibenclamide for duration of 10 weeks. This study demonstrated a highly positive correlation of plasma leptin levels with BMI, plasma insulin and insulin resistance. No gender specific differences were observed in leptin concentrations. The study, however, failed to demonstrate any possible relationship between glycemic control as assessed by blood sugars/ glycosylated hemoglobin (HbAlc) and plasma leptin. The administration of glibenclamide or glimepiride significantly lowered blood glucose levels coupled with a decrease in (HbAlc). Both the drugs increased insulin concentrations. Glibenclamide increased leptin levels but they remained unaltered with glimepiride. Glibenclamide and glimepiride were found to be equally effective in their glucose lowering action. However, the patients receiving glibenclamide experienced higher episode of hypoglycaemic spells than those receiving glimepiride.
منابع مشابه
Effect of fenugreek (Trigonella foenum graecum) extract on insulin levels in normal and streptozotocin-diabetic rats
In traditional practice medicine, plants are used in many countries to control diabetes mellitus. The hypoglycaemic actions of these medicinal plants are beings studied. Fenugreek (Trigonella foenum graecum) has been documented as a traditional treatment of diabetes. In the present study, oral administration of alcoholic fenugreek extract (0.1, 0.25, 0.5 g/kg body wt.) and glibenclamide (600 mg...
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ورودعنوان ژورنال:
- Indian journal of physiology and pharmacology
دوره 52 1 شماره
صفحات -
تاریخ انتشار 2008